Help Study Mendelian Pigs

We use research to help design our virtual laboratories. Some studies we do on our own, but for many we need help from faculty willing to try a lab in their classes, and a new study on our latest genetics lab is one of those. If you are teaching a class this fall (2010) where you discuss basic genetics, I'd like to invite you to help us test our newest lab, Mendelian Pigs.

The Mendelian Pigs lab came about from a survey we did of students understanding of population genetics. We found that as students tried to learn the rules of how allele frequencies change over generations, they were often getting stuck on basic concepts in Mendelian genetics such as what dominant and recessive meant. So as part of our CytoBeaker project to build a set of cell, molecular biology, and genetics teaching modules, we are designing a new lab that starts with some basic Mendelian genetics, and then shows the connection to population genetics. We have a more detailed description here.

Do you have a genetics, introductory biology, or evolutionary biology classes where you would be willing to use Mendelian Pigs, along with 15 - 20 minute pre- and post-tests? If so, please write me or our assessment coordinator Joel Abraham. We'll give you more details on the study protocol and goals, and get you set up to participate. The data from you and your students will contribute to making the lab better, and we'll also publish the results so other authors can learn from our approach to this material. Thanks in advance.

"In a simulation study

"In a simulation study different designs for a pure line pig population were compared for efficiency of mapping QTL using the variance component method. Phenotypes affected by a Mendelian QTL, a paternally expressed QTL, a maternally expressed QTL or by a QTL without an effect were simulated. In all alternative designs 960 progeny were phenotyped. Given the limited number of animals there is an optimum between the number of families and the family size. Estimation of Mendelian and parentally expressed QTL is more efficient in a design with large family sizes. Too small a number of sires should be avoided to minimize chances of sires to be non-segregating. When a large number of families is used, the number of haplotypes increases which reduces the accuracy of estimating the QTL effect and thereby reduces the power to show a significant QTL and to correctly position the QTL. Dense maps allow for smaller family size due to exploitation of LD-information. Given the different possible modes of inheritance of the QTL using 8 to16 boars, two litters per dam was optimal with respect to determining significance and correct location of the QTL for a data set consisting of 960 progeny. The variance component method combining linkage disequilibrium and linkage analysis seems to be an appropriate choice to analyze data sets which vary in marker density and which contain complex family structures. replica watches"

Mendelian Pigs

Is this something that a home school group could do? Mike http://www.healthykitchenplus.com

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